Elsa Lanchester plays both Mary Shelley in the beginning of the movie and the Monster's mate at the end of the film. She is only credited as Shelley in the closing credits. The Monster's mate is credited as "?".
The opening preamble between Mary Shelley, Lord Byron and Percy Bysshe Shelley is based upon an actual event that took place in 1816 in which the three of them, as well as John William Polidori and Claire Clairmont spent an evening on Lake Geneva where Shelley was first inspired to write her novel Frankenstein. This affair formed the basis of the 1986 Ken Russell film Gothic.
Doctor Pretorius is the only character in the film to refer to the Monster's Mate as the Bride of Frankenstein.
The Bride of Frankenstein was partially remade as The Bride in 1985. Actress Jennifer Beals played the role of the Monster's Mate and was given the name Eva. The film presupposes that both the Monster and the Bride survived the explosion that originally claimed them in James Whale's film.
The scene where the Monster meets the blind hermit was lampooned in Mel Brooks' 1974 comedy Young Frankenstein. Also in the film, Madeline Kahn is seen wearing the distinctive hairstyle of the Bride of Frankenstein.
The 1989 horror/comedy Bride of Re-Animator borrows heavily from this story. The premise of the film shows Doctor Herbert West and his reluctant assistant Dan Cain reconstructing a female body from spare parts, using the heart of Dan's late lover, Megan Halsey as the battery for the creature, working under the belief that Meg's consciousness could be revived through her heart. Naturally, everything goes awry and frenetic reanimate chaos ensues.
The Bride of Frankenstein was briefly featured in the 1998 slasher/comedy Bride of Chucky and served as an inspiration for both the film and co-star Jennifer Tilly's character, Tiffany. In the film, Tiffany watches the climax from The Bride of Frankenstein and is greatly moved by the scene, feeling that it is a great, if tragic, love story.
Another pastiche of the Bride is the character of Lisa from the 1985 John Hughes comedy Weird Science. Teenagers Gary Wallace (Anthony Michael Hall) and Wyatt Donnelly (Ilan Mitchell-Smith) create their own woman using incantations, candles, a doll, womens' undergarments and computer equipment. Video and audio clips from The Bride of Frankenstein are incorporated into the film. Colin Clive's infamous line "She's alive!" is mixed into the "Weird Science" theme song by Ira Newborn.